10 dab

10 dab

1: Grobosch T, Schwarze B, Stoecklein D, Binscheck T. Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry. J Anal Toxicol. 2012 Jan-Feb;36(1):36-43. doi: 10.1093/jat/bkr012. PubMed PMID: 22290751.

2: Zhang JF, Gong S, Guo ZG. Effects of different elicitors on 10-deacetylbaccatin III-10-O-acetyltransferase activity and cytochrome P450 monooxygenase content in suspension cultures of Taxus cuspidata cells. Cell Biol Int Rep (2010). 2010;18(1):e00009. doi: 10.1042/CBR20110001. Epub 2011 Apr 8. PubMed PMID: 23119144; PubMed Central PMCID: PMC3475439.

3: Fu Y, Zu Y, Li S, Sun R, Efferth T, Liu W, Jiang S, Luo H, Wang Y. Separation of 7-xylosyl-10-deacetyl paclitaxel and 10-deacetylbaccatin III from the remainder extracts free of paclitaxel using macroporous resins. J Chromatogr A. 2008 Jan 4;1177(1):77-86. Epub 2007 Nov 17. PubMed PMID: 18054030.

4: Georgopoulou K, Smirlis D, Bisti S, Xingi E, Skaltsounis L, Soteriadou K. In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes. Planta Med. 2007 Aug;73(10):1081-8. Epub 2007 Aug 9. PubMed PMID: 17691059.

5: Guo B, Kai G, Gong Y, Jin H, Wang Y, Miao Z, Sun X, Tang K. Molecular cloning and heterologous expression of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus x media. Mol Biol Rep. 2007 Jun;34(2):89-95. Epub 2006 Nov 9. PubMed PMID: 17094009.

6: Frapolli R, Marangon E, Zaffaroni M, Colombo T, Falcioni C, Bagnati R, Simone M, D’Incalci M, Manzotti C, Fontana G, Morazzoni P, Zucchetti M. Pharmacokinetics and metabolism in mice of IDN 5390 (13-(N-Boc-3-i-butylisoserinoyl)-C-7,8-seco-10-deacetylbaccatin III), a new oral c-seco-taxane derivative with antiangiogenic property effective on paclitaxel-resistant tumors. Drug Metab Dispos. 2006 Dec;34(12):2028-35. Epub 2006 Sep 8. PubMed PMID: 16963486.

7: Barboni L, Giarlo G, Ballini R, Fontana G. 14Beta-hydroxy-10-deacetylbaccatin III as a convenient, alternative substrate for the improved synthesis of methoxylated second-generation taxanes. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5389-91. Epub 2006 Aug 4. PubMed PMID: 16890428.

8: Hanson RL, Parker WL, Patel RN. Enzymatic C-4 deacetylation of 10-deacetylbaccatin III. Biotechnol Appl Biochem. 2006 Sep;45(Pt 2):81-5. PubMed PMID: 16722823.

9: Yang T, Li M, Chen JM. Conversion of taxane glycosides to 10-deacetylbaccatin III. Nat Prod Res. 2006 Feb;20(2):119-24. PubMed PMID: 16319004.

10: Fang J, Ewald D. Expression cloned cDNA for 10-deacetylbaccatin III-10-O-acetyltransferase in Escherichia coli: a comparative study of three fusion systems. Protein Expr Purif. 2004 May;35(1):17-24. PubMed PMID: 15039061.

10 dab 1: Grobosch T, Schwarze B, Stoecklein D, Binscheck T. Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III,


  • 7,10-Dimethoxy-10-DABIII &nbsp&nbsp&nbsp
  • CAS No.:183133-94-0
  • Formula: C31H40O10
  • Molecular Weight: 572.64300
  • Synonyms:7,10-dimethyl-10-DAB; 7,10-dimethylbaccatin III; 7,10-Dimethoxy-10-DABIII
  • Synthesis Route (22)
  • Precursor and Products (22)
  • NMR Spectrum
  • 10-O-methyl-7-O-triethylsilyl-10-DAB &nbsp&nbsp&nbsp
  • CAS No.:160084-70-8
  • Formula: C36H52O10Si
  • Molecular Weight: 672.87800
  • Synonyms:10-deacetyl-10-methyl-7-triethylsilyl baccatin III; 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene; 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene
  • Precursor and Products (2)
  • 1H NMR prediction
  • 7,10-di-O-chloroacetyl-10-DAB &nbsp&nbsp&nbsp
  • CAS No.:500726-10-3
  • Formula: C33H38Cl2O12
  • Molecular Weight: 697.55400
  • Synonyms:7,10-di-O-chloroacetyl-10-DAB
  • Synthesis Route (1)
  • Precursor and Products (1)
  • 1H NMR prediction
  • 14β-Hydroxy 10-Deacetyl Baccatin III &nbsp&nbsp&nbsp
  • CAS No.:145533-34-2
  • Formula: C29H36O11
  • Molecular Weight: 560.59000
  • Synonyms:4|A-Hydroxy-10-DAB
  • NMR Spectrum
  • 13-epi-10-DAB &nbsp&nbsp&nbsp
  • CAS No.:172018-16-5
  • Formula: C29H36O10
  • Molecular Weight: 544.59000
  • Synonyms:13-epi-10-DAB
  • NMR Spectrum

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